• The association between insomnia, c-reactive protein, and chronic low back pain: Cross-sectional analysis of the HUNT study, Norway 

      Ho, Kevin Kwan Ngai; Simic, Milena; Småstuen, Milada Cvancarova; de Barros Pinheiro, Marina; Ferreira, Paulo Herrique; Johnsen, Marianne Bakke; Heuch, Ingrid; Grotle, Margreth; Zwart, John-Anker; Nilsen, Kristian Bernhard (Scandinavian Journal of Pain;Volume 19: Issue 4, Journal article; Peer reviewed, 2019-07-09)
      Background and aims: Chronic low back pain (chronic LBP) is the number one cause for years lived with disability among 301 diseases and injuries analyzed by The Global Burden of Disease study 2013. Insomnia is highly ...
    • Associations between the number of children, age at childbirths and prevalence of chronic low back pain: the Nord-Trøndelag Health Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Storheim, Kjersti; Zwart, John-Anker (BMC Public Health;20, Article number: 1556 (2020), Journal article; Peer reviewed, 2020-10-15)
      Background: Associations between childbirths and subsequent risk of low back pain (LBP) have not been clarified. Changes in sex hormone levels or lumbar posture during pregnancy may have an impact on LBP later in life. The ...
    • COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study 

      Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Karen, Rosendahl; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei (Peer reviewed; Journal article, 2023)
      Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ...
    • Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity 

      Bakker, Mark K.; Kanning, Jos P.; Abraham, Gad; Martinsen, Amy; Winsvold, Bendik Kristoffer Slagsvold; Zwart, John Anker Henrik; Bourcier, Romain; Sawada, Tomonobu; Koido, Masaru; Kamatani, Yoichiro; Morel, Sandrine; Amouyel, Philippe; Debette, Stéphanie; Bijlenga, Philippe; Berrandou, Takiy; Ganesh, Santhi K.; Bouatia-Naji, Nabila; Jones, Gregory; Bown, Matthew; Rinkel, Gabriel J.E.; Veldink, Jan H.; Ruigrok, Ynte M.; Aamodt, Anne Hege; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Sandset, Else Charlotte; Kristoffersen, Espen Saxhaug; Ellekjær, Hanne; Heuch, Ingrid; Nielsen, Jonas Bille; Hagen, Knut; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Børte, Sigrid; Schmidt, Helena; Stubhaug, Audun; Nielsen, Christopher Sivert; Johnsen, Marianne Bakke; Sandvei, Marie Søfteland (Peer reviewed; Journal article, 2023)
      BACKGROUND: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to ...
    • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions 

      Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Brain;Volume 145, Issue 3, Peer reviewed; Journal article, 2021-11-11)
      Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ...
    • Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC 

      Lie, Marie; Pedersen, Linda Margareth; Heuch, Ingrid; Winsvold, Bendik K S; Gjerstad, Johannes; Hasvik, Eivind Olay; Nygaard, Øystein Petter; Grotle, Margreth; Matre, Dagfinn; Zwart, John Anker Henrik; Nilsen, Kristian Bernhard (Frontiers in Genetics;January 2022 | Volume 12 | Article 757632, Peer reviewed; Journal article, 2022-01-24)
      In a recently published genome-wide association study (GWAS) chronic back pain was associated with three loci; SOX5, CCDC26/GSDMC and DCC. This GWAS was based on a heterogeneous sample of back pain disorders, and it is ...
    • Menopausal hormone therapy, oral contraceptives and risk of chronic low back pain: the HUNT Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Storheim, Kjersti; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)
      Background There are indications that use of menopausal hormone therapy (MHT) and oral contraceptives (OC) increases the risk of low back pain (LBP), with higher oestrogen levels involved in the underlying mechanisms. ...
    • Obesity in young adulthood: The role of physical activity level, musculoskeletal pain, and psychological distress in adolescence (the hunt-study) 

      Guddal, Maren Hjelle; Stensland, Synne; Småstuen, Milada Cvancarova; Johnsen, Marianne Bakke; Heuch, Ingrid; Zwart, John-Anker; Storheim, Kjersti (International Journal of Environmental Research and Public Health;Volume 17, Issue 12, Journal article; Peer reviewed, 2020-06-26)
      The global obesity epidemic raises long-term health concerns which underline the importance of preventive efforts. We aimed to investigate individual and combined effects of common health problems in adolescence on the ...